For those of us following the confounding opioid epidemic, there’s more unhealthy news. Stanford researchers have decided that taking sturdy prescription painkillers together with sleeping pills is associated with higher danger of overdose.
Ninety-one People die daily from an opioid overdose – a number that has quadrupled since 1999, according to the center for Illness Control and Prevention.
A examine launched right now in the BMJ reveals that nearly 30 % of those fatal opioid overdoses in the United States also involve benzodiazepines, that are widely used to treat anxiety and sleep problems.
It looks like a no-brainer that you simply shouldn’t mix the two. However medical doctors seem like increasingly prescribing both – at the same time. Using a big sample of privately insured patients from 2001 to 2013, the researchers discovered that concurrent sleeping pill and オンライン 睡眠薬 opioid prescribing elevated by 80 p.c over that point period.
Stanford anesthesiologist Eric Sun, MD, PhD, is lead author of the examine, and Sean Mackey, MD, PhD, chief of ache medicine, is senior writer.
“It’s in all probability pretty well known that prescribing an opioid and a benzodiazepine is a potentially risky mixture,” Sun stated. “One of the targets of our paper was to see the extent to which this nonetheless occurred regardless of this data. General, we found that it occurs, but more importantly, it has been growing over time.”
The researchers set out to determine trends in concurrent use of a benzodiazepine and an opioid – and to identify the influence of these tendencies on admissions to hospital and emergency room visits for opioid overdose.
Their examine concerned over 300,000 privately insured individuals aged 18 to sixty four who had been prescribed an opioid and a benzodiazepine. They discovered that 9 percent of opioid users also used a benzodiazepine in 2001, rising to 17 % in 2013, or an eighty p.c relative increase.
“This increase was pushed mainly by will increase amongst intermittent, versus chronic, opioid customers,” the authors wrote.
Compared with opioid customers who didn’t use benzodiazepines, concurrent use of both drugs was related to a considerably higher risk of an emergency room visit or inpatient admission for opioid overdose.
This is an observational examine, nonetheless, so no firm conclusions might be drawn about trigger and effect. But if this association is found to be causal, elimination of the concurrent use of benzodiazepines and opioids “could scale back the population threat of an emergency room visit or inpatient admission for opioid overdose by 15 %,” the authors said.